About Fabenol®

Fabenol® is an alpha-amylase inhibitory natural extract obtained from Phaseolus vulgaris (common bean, kidney bean) that blocks the digestion of dietary starch, thereby offering potential benefits in the maintenance of healthy blood sugar levels and optimal body composition.

The emergence of obesity as the leading public health problem in the United States is a matter of great concern. Over 58 million adults in the U.S. are obese and about one in five American children and adolescents is overweight. Obesity greatly increases the risk of premature death, and it is a major risk factor for developing chronic conditions such as diabetes, heart disease, high blood pressure, gallbladder disease, arthritis, lung problems and some of the more common forms of cancer. According to government statistics, obesity accounts for about three hundred thousand premature deaths in the United States each year.

The increased incidence of obesity is attributed to improper diet and a sedentary lifestyle. Therefore the quality of our lives depends upon appropriate lifestyle choices. We have to shed down our excess weight if we want to lead a happy life. Reduction of fat storage / overweight of individuals requires much and prolonged effort. Diet restrictions and extreme exercise regimens have poor success rates in weight reduction. However, smart nutritional choices supplemented with natural weight management products in combination with appropriate exercise regimens would serve the purpose.

Excess carbohydrates in the diet are ultimately converted to fats and stored in the body. In both plants and animals, starch is broken down by amylases and maltase to yield glucose. Plants break down starch during seed germination or tuber sprouting to supply the energy and carbon skeletons. Animals and fungi break down plant starch to obtain glucose for their own metabolism. The enzymes that catalyze the conversion of starch (a polysaccharide) into sugar molecules (monosaccharides) are called amylases. Surprisingly, plants usually contain amylase inhibitory compounds in the same organs (seeds and tubers) where the starch is stored, to ward off bacterial, fungal and animal predators. No parallels exist in mammalian systems.

Currently, scientists focus their interest on the amylase inhibitors produced by plants to block amylase activity in the human digestive tract. An amylase inhibitor acts as an antinutrient that obstructs the digestion of starch and absorption of glucose. Therefore amylase inhibitors are therapeutically valued in conditions such as diabetes (to reduce blood sugar levels) and in weight management. One of the conventionally used drugs in the management of diabetes, Acarbose, is a complex oligosaccharide that delays the digestion of ingested carbohydrates, thereby resulting in a smaller rise in blood glucose concentration following food intake. Acarbose inhibits the action of pancreatic amylase in breaking down starch, thereby achieving this effect.